ncRNA name | caspase-14 siRNA |
ncRNA Category | siRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | human RPE cell line ARPE-19 |
Methods | siRNA transfection, Western blot, TUNEL assay |
Expression pattern | associated |
Functional description | Caspase-14 expression in ARPE-19 cells increased FITC-dextran leakage through the confluent monolayer and decreased the transcellular electrical resistance (TER). These effects of HG were prevented by caspase-14 knockdown. Furthermore, caspase-14 knockdown prevented the HG-induced activation of caspase-1 and caspase-9, the only activated caspases by HG. |
PubMed ID | 25121097 |
Year | 2014 |
Title | Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema. |
Drug-related ncRNA | NO |
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